diff --git a/cluster.go b/cluster.go
index 3807265..c40e18d 100644
--- a/cluster.go
+++ b/cluster.go
@@ -86,7 +86,7 @@ func (opt *ClusterOptions) init() {
 		opt.MaxRedirects = 3
 	}
 
-	if (opt.RouteByLatency || opt.RouteRandomly) && opt.ClusterSlots == nil {
+	if opt.RouteByLatency || opt.RouteRandomly {
 		opt.ReadOnly = true
 	}
 
@@ -153,9 +153,13 @@ func (opt *ClusterOptions) clientOptions() *Options {
 		IdleTimeout:        opt.IdleTimeout,
 		IdleCheckFrequency: disableIdleCheck,
 
-		readOnly: opt.ReadOnly,
-
 		TLSConfig: opt.TLSConfig,
+		// If ClusterSlots is populated, then we probably have an artificial
+		// cluster whose nodes are not in clustering mode (otherwise there isn't
+		// much use for ClusterSlots config).  This means we cannot execute the
+		// READONLY command against that node -- setting readOnly to false in such
+		// situations in the options below will prevent that from happening.
+		readOnly: opt.ReadOnly && opt.ClusterSlots == nil,
 	}
 }
 
diff --git a/cluster_test.go b/cluster_test.go
index 64acecf..27d2a1c 100644
--- a/cluster_test.go
+++ b/cluster_test.go
@@ -1020,6 +1020,66 @@ var _ = Describe("ClusterClient", func() {
 
 		assertClusterClient()
 	})
+
+	Describe("ClusterClient with ClusterSlots with multiple nodes per slot", func() {
+		BeforeEach(func() {
+			failover = true
+
+			opt = redisClusterOptions()
+			opt.ReadOnly = true
+			opt.ClusterSlots = func(ctx context.Context) ([]redis.ClusterSlot, error) {
+				slots := []redis.ClusterSlot{{
+					Start: 0,
+					End:   4999,
+					Nodes: []redis.ClusterNode{{
+						Addr: ":8220",
+					}, {
+						Addr: ":8223",
+					}},
+				}, {
+					Start: 5000,
+					End:   9999,
+					Nodes: []redis.ClusterNode{{
+						Addr: ":8221",
+					}, {
+						Addr: ":8224",
+					}},
+				}, {
+					Start: 10000,
+					End:   16383,
+					Nodes: []redis.ClusterNode{{
+						Addr: ":8222",
+					}, {
+						Addr: ":8225",
+					}},
+				}}
+				return slots, nil
+			}
+			client = cluster.newClusterClient(ctx, opt)
+
+			err := client.ForEachMaster(ctx, func(ctx context.Context, master *redis.Client) error {
+				return master.FlushDB(ctx).Err()
+			})
+			Expect(err).NotTo(HaveOccurred())
+
+			err = client.ForEachSlave(ctx, func(ctx context.Context, slave *redis.Client) error {
+				Eventually(func() int64 {
+					return client.DBSize(ctx).Val()
+				}, 30*time.Second).Should(Equal(int64(0)))
+				return nil
+			})
+			Expect(err).NotTo(HaveOccurred())
+		})
+
+		AfterEach(func() {
+			failover = false
+
+			err := client.Close()
+			Expect(err).NotTo(HaveOccurred())
+		})
+
+		assertClusterClient()
+	})
 })
 
 var _ = Describe("ClusterClient without nodes", func() {